• Azithromycin (as Azithromycin Dihydrate) – 250 mg

• Lactic Acid Bacillus – 60 Million Spores

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PACKING: 10 x 6 (Blister)

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Dosage Form

Tablet / Capsule (as marketed)

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Pharmacological Classification

• Azithromycin: Macrolide Antibiotic

• Lactic Acid Bacillus: Probiotic

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Mechanism of Action

Azithromycin is a broad-spectrum macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms. This action prevents bacterial growth and replication.

Lactic Acid Bacillus is a beneficial probiotic organism that helps restore normal intestinal flora altered during antibiotic therapy. It reduces the risk of antibiotic-associated diarrhea and maintains gut microbial balance.

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Indications (Therapeutic Uses)

PIDO 250 is indicated for the treatment of mild to moderate bacterial infections such as:

• Upper respiratory tract infections (pharyngitis, tonsillitis, sinusitis)

• Lower respiratory tract infections (bronchitis, pneumonia)

• Otitis media

• Skin and soft tissue infections

• Certain gastrointestinal and enteric infections

• Typhoid fever (as per sensitivity)

Note: Use should be based on clinical evaluation and bacterial sensitivity.

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Dosage & Administration

• To be taken strictly as prescribed by a registered medical practitioner.

• Usually administered once daily.

• May be taken with or without food.

• Complete the full prescribed course to prevent antibiotic resistance.

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Contraindications

• Hypersensitivity to Azithromycin, erythromycin, or other macrolide antibiotics

• Severe hepatic impairment

• History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use

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Warnings & Precautions

• Use cautiously in patients with liver disorders.

• Caution in patients with cardiac arrhythmias or prolonged QT interval.

• Not effective against viral infections (e.g., common cold, flu).

• Avoid unnecessary or prolonged use to prevent antimicrobial resistance.

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Adverse Effects

Common side effects may include:

• Nausea

• Vomiting

• Abdominal pain

• Diarrhea

• Dyspepsia

Rare but serious:

• Allergic reactions (rash, itching, angioedema)

• Hepatotoxicity

• QT prolongation

Patients should seek immediate medical attention if severe reactions occur.

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Drug Interactions

• Antacids containing aluminum or magnesium

• Warfarin (monitor INR)

• Digoxin

• Other QT-prolonging drugs

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Use in Special Populations

Pregnancy: Use only if clearly needed and prescribed by a physician.
Lactation: Use with caution under medical supervision.
Pediatric & Geriatric: Dose adjustment may be required based on clinical condition.

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Storage

Store in a cool, dry place below 25°C.
Protect from moisture and direct sunlight.
Keep out of reach of children.

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